I’ve always been intrigued by the bond between these three characters, the ones who were there from the beginning, and what it was like for Shepard and the Virmire Survivor to get over losing that third, crucial point of their trinity. They are no longer a trident - just a notched blade.
Shepard may have gone on to have closer friends, like Garrus, other love interests like Liara, and other crew who piece by piece came together to watch Shepard’s back, offer a helping hand when it was needed. But there’s just something about that bond, like the little thumbprint of glue you can’t scruboff an otherwise bare surface.
I imagine that the Virmire death haunts them both. Can you imagine what Shepard felt like after Horizon? Forget the romance. Forget Bioware’s bad writing. What a punch in the gut to have the one person left who knew you before you were The Shepard, just turn and walk away, with all that doubt in their eyes? How hollow would that make you feel?